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Cyclin E, p21 binding domains are PCNA binding domain, Cdk2/Cyclin E is required for S phase entry, Cyclin E overexpression decreases (100) Cell size, Cdk2/Cyclin E is blocked by (100,123) Abs against Cyclin E, 2 forms (100) in (100) Mammalian cells, 2 forms (100) are produced by (100) Alternate splicing, 15 AA N-terminal deletion is Exon 2, 2 forms (100) are Class II, E-S differ by (100) Exon 2, 47 base pair deletion is Exon 2