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This Concept Map, created with IHMC CmapTools, has information related to: SNF-5A-(3), group of blood lipids(fats) accumulate fat accumulation can partially or completely occlude arterial blood flow, fat accumulation can partially or completely occlude arterial blood flow development of fatty streaks which contain atherogenic lipoproteins and macrophage foam cells, mechanical injury injury to the intimal(innermost) layer of the artery, fat accumulation can partially or completely occlude arterial blood flow can lead to Infarction occurs when severe ischemia is prolonged and irreversible damage to tissue results, plaque rupture causes more severe damage such as seen in acute coronary syndrome ischemia occurs when insufficient oxygen is supplied to meet the requirements of the myocardium, proliferation can narrow the artery enough to compromise the flow of the blood or completely occlude arterial blood flow can lead to Infarction occurs when severe ischemia is prolonged and irreversible damage to tissue results, elevated levels of LDL-C decreased levels of HDL-C mechanical injury, stable plaque is a white, glistening fibrous elevation that covers a lipid core (mainly cholesterol) plaque ruptures and thrombosis and vosoconstriction obstruct the lumen, after intimal injury occurs, platelets form a cluster at the arterial wall producing a peptide that stimulates the proliferation of the smooth muscle cells of the intima, risk/causative factor: hypertension elevated levels of LDL-C decreased levels of HDL-C, ischemia occurs when insufficient oxygen is supplied to meet the requirements of the myocardium leading to Stable/Unstable Angina, causing chemical injury to the intimal wall injury to the intimal(innermost) layer of the artery, streaks form between the endothelium and the internal elastic lamina lesion made up of an extra cellular lipid core and layers of smooth muscle and connective tissue matrix eventuall forms a fibrous cap, carbon monoxide elevating toxin levels in blood stream causing chemical injury to the intimal wall, stable or unstable plaque develops unstable plaque has a liquid lipid core its elevated enough to partially or completely occlude the blood flow of an artery, risk/causative factor: factory worker carbon monoxide elevating toxin levels in blood stream, weakening of the intimal wall injury to the intimal(innermost) layer of the artery, B/P elevation proliferation can narrow the artery enough to compromise the flow of the blood or completely occlude arterial blood flow, injury to the intimal(innermost) layer of the artery after intimal injury occurs, platelets form a cluster at the arterial wall, a peptide that stimulates the proliferation of the smooth muscle cells of the intima proliferation can narrow the artery enough to compromise the flow of the blood or completely occlude arterial blood flow