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This Concept Map, created with IHMC CmapTools, has information related to: Sm Cell Cancer, Metastasis- tumor invades surrounding tissues Lymphatic spread is related to the number, structure, and location of lymph nodes and vessels, Small cell lung cancer Carcinogenesis Initiation- irreversible event that can lead to cancer if it does not interfere with the cells ability to divide,, Small cell lung cancer S/sx thrombocytopenia, Small cell lung cancer Comorbidities venous ulcers, Small cell lung cancer Etiology Oncogene activation, Small cell lung cancer Diagnostics Biopsies, when the DNA is damaged supressor genes are turned off (Lung suppressor gene- FUS1) When proto-oncogenes are turned off they are called oncogenes, Surgery control, Promotion- the development phase of a tumor which can take months to years promoters drugs, Promotion- the development phase of a tumor which can take months to years promoters chemicals, Small cell lung cancer S/sx loss of function, Physical carcinogens Radiation, Penetration by a carcinogen can damage DNA carcinogens chemicals, External Factors Chemical carcinogens, Metastasis- tumor invades surrounding tissues Enzymes make large pores in blood vessels alllowing tumor cells to enter the blood, Penetration by a carcinogen can damage DNA carcinogens viruses, Small cell lung cancer Comorbidities CHF, Personal Factors Genetic risk, Oncogene activation proto-oncogenes are supressed by "supressor genes" from birth, Small cell lung cancer Treatments Immunotherapy