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This Concept Map, created with IHMC CmapTools, has information related to: Neonatal Jaundice, Indirect Hyperbili Dbili < 15% TBili GI Increased enterohep recirc -PYLORIC STENOSIS -DUODENAL STENOSIS -ANNULAR PANCREAS, Indirect Hyperbili Dbili < 15% TBili GI Bili Conjugation (less gluc. xferase) CRIGLER-NAJJAR GILBERT'S, Direct Hyperbili -DBili > 15% T Bili ALWAYS PATHOLOGIC ID Hepatitis HEP A,B,C EBV TORCH VARICELLA HERPES TB, Neonatal Jaundice ALARMS Jaundice ឈhrs of age Bili rises ɱ-8 mg/dL/day Bili rises ɬ.5mg/dL/hr -hemolysis, Indirect Hyperbili Dbili < 15% TBili Breast Breast Milk ɭ wk of life -high b-glucuronidase in milk, Indirect Hyperbili Dbili < 15% TBili Physiologic Jaundice 1-Increased bili load on liver 2-Glucuronyl transferase is slow, Indirect Hyperbili Dbili < 15% TBili RBCs Bruise CEPHALOHEMATOMA CAPUT SUCCEDENEUM BIRTH TRAUMA, Neonatal Jaundice Non-Physiologic Jaundice Indirect Hyperbili Dbili < 15% TBili, Neonatal Jaundice WORK-UP CBC/RETIC COUNT/SMEAR HEPATIC U/S, HEP SEROLOGIES, SCANS OF BILIARY TREE SEPSIS W/U, Indirect Hyperbili Dbili < 15% TBili RBCs Hemolysis SPHEROCYTOSIS ELLIPTOCYTOSIS PK-DEFICIENCY ABO-Rh INCOMPATIBILITY, Neonatal Jaundice TREAT PHOTOTHERAPY EXCHANGE TRANSFUSION, Direct Hyperbili -DBili > 15% T Bili ALWAYS PATHOLOGIC GI Obstructive CHOLEDOCHAL CYST BILIARY ATRESIA CHOLESTASIS FROM TPM CYSTIC FIBROSIS, Indirect Hyperbili Dbili < 15% TBili Endocrine IEMs HYPOTHYROID, Indirect Hyperbili Dbili < 15% TBili Breast Breast Feeding -first week -suboptimal milk intake -dehydrate->less stool, Direct Hyperbili -DBili > 15% T Bili ALWAYS PATHOLOGIC Metabolic GALACTOSEMIA HERED FRUCTOSE INTOL TYROSINEMIA a1-AT DEFICIENCY, Neonatal Jaundice Physiologic Jaundice 1-Increased bili load on liver 2-Glucuronyl transferase is slow, Direct Hyperbili -DBili > 15% T Bili ALWAYS PATHOLOGIC ID SEPSIS, Indirect Hyperbili Dbili < 15% TBili ID SEPSIS, Neonatal Jaundice Non-Physiologic Jaundice Direct Hyperbili -DBili > 15% T Bili ALWAYS PATHOLOGIC, Direct Hyperbili -DBili > 15% T Bili ALWAYS PATHOLOGIC GI Hepatitis HEP A,B,C EBV TORCH VARICELLA HERPES TB