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This Concept Map, created with IHMC CmapTools, has information related to: ClassicalDrugs, High Agonist Concentration produces Parallel shift to right of Agonist's DR curve, Sigmoidal DR Relationship characterised by ED50 (potency), Endogenous Ligand/Agonist binds to Endogenous Receptor, Competitive Antagonists block effect of agonists to activate Endogenous Transduction Mechanism, Antagonists bind irreversibly to agonist receptor site Noncompetitive Antagonists, A reduction in the height or amplitude of the Agonist's DR curve but no change in ED50, Competitive Antagonists effects can be surmounted by High Agonist Concentration, Transduction Mechanism producing a Biological Response Similar to Endogenous Ligand, Reduction in maximal effect of Agonist producing A reduction in the height or amplitude of the Agonist's DR curve, Drugs are either Agonists, Sigmoidal DR Relationship characterised by Maximum Response (Efficacy), Antagonists or allosterically change conformation of receptor site Noncompetitive Antagonists, Endogenous Receptor activates Transduction Mechanism, Antagonists bind reversibly to agonist receptor site Competitive Antagonists, Noncompetitive Antagonists prevent agonist from activating Transduction Mechanism, Biological Response Similar to Endogenous Ligand variable doses will define its Sigmoidal DR Relationship, Drugs are either Antagonists, Parallel shift to right of Agonist's DR curve appearing as increased ED50 of agonist (but same maximum), Agonists binds reversibly to same site as endogenous agonist Endogenous Receptor, Transduction Mechanism resulting in Reduction in maximal effect of Agonist