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This Concept Map, created with IHMC CmapTools, has information related to: MELAS 2, DNA repair leads to increased likelihood for mutation, slurred speech together are suggestive of mitochondrial disorder, ragged red fibers indicated by skeletal muscle biposy, hearing loss together are suggestive of mitochondrial disorder, invasive tests show elevated lactate, pryuvate in CSF, TCA cycle occurs in mitochondria, Medadione (vitamin K3) donates electrons to Cytochrome C, DCA inhibits Pyruvate dehydrogenase kinase, short stature together are suggestive of mitochondrial disorder, Electron Transport Chain including Complex IV activity, anaerobic glycolysis leads to elevated lactic acid, Complex IV activity deficiency causes increased release of reactive oxygen species, replicative segregation leads to amount of heteroplasmy, buildup of NADH causes disruption of TCA cycle, Carnitine stimulates uptake of long-chain fatty acids, mitochondria abnormalities cause ragged red fibers, Idebonone analog of CoQ10, 17 year old white female physical exam shows ptosis, hemiparesis are stroke-like symptoms, Metabolic Therapies include Succinate