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This Concept Map, created with IHMC CmapTools, has information related to: Tangier Disease.cmap, phospholipids Thus, they cannot produce HDLs, LDLRs in the peripheral tissues, APO A-1 cannot join with cholesterol, ABCA1, ATP-binding cassette transporter protein prevents the release (from peripheral tissues) of Vitamin E, lipid deposits of schwann cells of neurons causing peripheral neuropathy, binds and hydrolyzes ATP providing energy for the lipidation of APO A-1, HDLs to cholesterol ester, person homozygous for ABCA1 mutation often presents with Low LDL levels, Family History of Tangier's Disease, VLDL in order to to activate lipoprotein lipase, lipoprotein lipase which normally reduces plasma triglyceride levels, ABCA1 mutation is located on 9q31 locus of long arm of chromosome 9, tissue foam cells which causes plaque formation on peripheral tissues, retinyl esters the buildup causes a yellow-orange pigmentation on plaque formation on peripheral tissues, ABCA1 mutation often presents with no activity of ABCA1, ATP-binding cassette transporter protein, higher in ratio number of larger oxidized LDL the creation of Foam cells on the endothelial cells of arteries, cholesterol ester from HDL to VLDL, normal LDL levels this combination leads to higher in ratio number of larger oxidized LDL, APO A-1 is endocytosed, ABCA1, ATP-binding cassette transporter protein prevents the release (from peripheral tissues) of Carotenoids