WARNING:
JavaScript is turned OFF. None of the links on this concept map will
work until it is reactivated.
If you need help turning JavaScript On, click here.
This Concept Map, created with IHMC CmapTools, has information related to: Homocysteinemia, dUDP converted to dUMP, Vitamin B6 required for the formation of cystathionine, S-Adenosylhomocysteine (SAH) hydrolyzed to homocysteine, C677 C to T variant leads to defficiency in methylenetetrahydrofolate reductase, homocysteine converted via methionine synthase to methionine, 35 year old man should take folic acid, 5-methyltetrahydrofolate converted via methionine synthase to tetrahydrofolate, homocysteine elevated levels promote oxidative damage, methylenetetrahydrofolate reductase converts 5,10-Methyl THF to 5-methyltetrahydrofolate, DNA hypomethylation leads to altered gene expression in endothelial cells, including decreased cyclin A transcription, MTRR methylates Cob (II) to methylcobalamin (Methyl-Cob III), vascular disease specific to carotid artery may lead to Stroke, cystathionine converted via y-cystathionase to Cysteine, altered production of neurotransmitters contributes to Mental retardation, decreased endothelial cell growth leads to increased vascular smooth muscle proliferation, 5-methyltetrahydrofolate decreased levels due to MTHFR deficiency causes decreased leves of methylcobalamin (Methyl-Cob III), MTRR enzyme which transfers methyl groups, MTRR methylates SAM to S-Adenosylhomocysteine (SAH), methylation potential defined as ratio of SAM: SAH S-Adenosylmethionine (SAM), methionine converted via s-adenosylmethionine synthetase and ATP to S-Adenosylmethionine (SAM)