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This Concept Map, created with IHMC CmapTools, has information related to: marasmus, high glucagon/insulin ratio activates Pyruvate carboxylase, Skeletal muscle continued breakdown in long term fasting state leads to muscle wasting, glycerol substrate for gluconeogenesis, low blood glucose short and long term fast also characterized by high glucagon/insulin ratio, prolonged fast glycogen stores depleted, unable to use glycogenolysis, high glucagon/insulin ratio leads to decrease in F 2,6 BP, Malonyl CoA inhibits CPT I, glutamate dehydrogenase and aminotransferase enzymes in reaction that create glutamate and alanine, fatty acid binds to serum albumin, high glucagon/insulin ratio phosphorylates and activates hormone sensitive lipase, PEP carboxylase stimulate gluconeogenesis, muscle wasting increases levels of serum creatinine, urine of patient, glucose used as the primary energy source in the brain, glucose made in the liver used to low blood glucose, gluconeogenesis creates glucose, patient initially short term fasting, patient presents with elevated cortisol levels, gluconeogenesis during prolonged fast active to only provide glucose to RBC, absense of insulin stimulates proteolysis