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This Concept Map, created with IHMC CmapTools, has information related to: A7 Week 31 Georgia Sonoma, Aldehyde dehydrogenase depletes NAD+, Cytochrome p450 2E1 5- to 10-fold increase in expression in Alcoholism, Cytochrome p450 2E1 oxidation of ethanol generates Acetaldehyde, Red blood cells have Heme, NAD+ ???? Free fatty acids, Backup of portal venous blood causes Caput medusae, Cytochrome p450 2E1 only significantly active under high blood alcohol levels, Alcohol dehydrogenase depletes NAD+, Urobilinogen secreted in Feces, Unconjugated bilirubin binds to Albumin, Total bilirubin [basic science one], Conjugated bilirubin released into Gut, TNF & other inflammatory cytokines if prolonged, leads to Chronic inflammation, NADH ???? NADH/NAD+, ethanol oxidized in liver by Cytochrome p450 2E1, TNF & other inflammatory cytokines if prolonged, leads to damaged endothelium, lipid peroxidation of cell membranes leads to damaged endothelium, Biliverdin reductase produces Unconjugated bilirubin, ethanol lyses intestinal gram-neg. bacteria, LPS stimulates release of TNF & other inflammatory cytokines