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This Concept Map, created with IHMC CmapTools, has information related to: Jessica edits of PE, Atorvastatin 20 mg qd MOA Inhibits HMG-CoA reductase conversion to mevalonate, a precusor of sterols, cholesterol., EFFECTS: ↓LDL, Triglycerides ↑ HDL ↓ Inflammation:↓ CRP ↓ Lipid Oxidation ↓ Thrombosis ↓ Platelet activation ↑ Endothelial Medial Vasodilation ↑ NO production ???? Preventing: atherosclerosis Thrombosis Inflammation Vasoconstriction Vascular & remodeling Plaque rupture, Virchow's Triad 3 conditions predispose for thrombus formation Hypercoagulability, Circulartory ???? -Immobility -Venous obstruction (obesity, tumor) -Varicose veins -Atrial fibrillation or LV dysfunction -Congenital abnormalities affecting venous anatomy -Low HR/BP, Case Study Peripheral Artery Disease (PAD) Narrowing of peripheral arteries, commonly the pelvis, legs & arms, Endothelial Dysfunction Pathophysiology between PAD & PVD Arterial & Venous Insufficiency, ↑ Tissue ACE-A II Growth factors matrix Vascular lesion & remodeling, ↑ NO prostacyclin EDHF results - Prevents Remodeling of: Myocyte growth Vascular smooth muscle growth ↑ Collagen - ↓ VSMC: concontration growth migration - ↓ Matrix synthesis - ↓ Platelet aggregation - ↓PAI-1 - ↑ tPA - ↓inflammation - ↑ Myocardial angiogensis, Case Study Peripheral Venous Disease (PVD) Inadequate return of venous blood from the legs to the heart, Venous Clots ???? Deep Vein Thrombosis (DVT), Causes 'oxidative stress' & imbalance in the functioning of endothelial cells leading to ↑ Tissue ACE-A II, Depends on LDL levels Optimal mg/dL Moderate Lower LDL 30%-40%, ↑ SREBP2 ???? ↓ Cholesterol- LDL, Virchow's Triad Testing Arterial & Venous Insufficiency, Atorvastatin 20 mg qd dosing Depends on LDL levels Optimal mg/dL, Endothelium is the inner lining of the BV. ???? Responsible for relaxation & contraction of the BV and releases substances which control blood clotting and immunity of the body, ↑ Local mediators VCAM ICAM cytokines Inflammation, EFFECTS: ↓LDL, Triglycerides ↑ HDL ↓ Inflammation:↓ CRP ↓ Lipid Oxidation ↓ Thrombosis ↓ Platelet activation ↑ Endothelial Medial Vasodilation ↑ NO production ???? Pleiotropic effects, Current medication Diabetes Metformin 500 mg bid, ↑ Tissue ACE-A II Proteolysis Plaque rupture