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This Concept Map, created with IHMC CmapTools, has information related to: Cancer lecture 1, MOA Guanine methylation to form Radical (from methylhydrazine), DNA Cross-Linking Agents Organoplatinum Complexes Cisplatin (Platinol), Cancer therapy Surgery (not metastasized), Cancer therapy Radiation, low basicity b/c aromatic grp slowest acting least toxic, Cancer therapy Immunotherapy, Cisplatin (Platinol), Cancer causes Virus, MOA -S & M phases disruption -binds to all DNA bases -Potent DNA polymerase inhibitor, S/N Mustards (N = safer) drugs Melphalan (Alkeran), MOA (2 paths, but path B preferred) Inhibits: DNA syntheis RNA production RNA translation, S/N Mustards (N = safer) ????, Chlorambucil (Leukeran) ????, Melphalan (Alkeran) ????, MOA Alkylation but NOT a mustard, DNA Cross-Linking Agents alkylating agents S/N Mustards (N = safer), Aziridinium Ion (active) ????, Radiation Localized & Selective, S/N Mustards (N = safer) drugs Cyclophosphamide (Cytoxan), Cancer causes Spontaneous