In this way, the NMDA receptor acts as a “coincidence detector” that detects the simultaneous activation of both Neuron A and Neuron B. As Donald Hebb hypothesized, when both neurons are activated at the same time, their connections are strengthened. Pre and postsynaptic mechanism for enhancing synaptic efficacy.
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Glutamate activation of NMDA receptor produces LTP. These receptors are both ... Maintenance of LTP may lie in non-NMDA receptors (such as AMPA receptors) ...
... (NMDA) receptor by glutamate is implicated in neurodegenerative disorders; This 28-week study compared memantine, an NMDA-receptor antagonist, with placebo in ...
... NMDA synapse is necessary for consciousness. Anesthetics abolish consciousness by interfering with the functioning of NMDA receptors. Conclusion: The NCC is ...
NMDA, AMPA, kainate; Gated Ca++ and Gated Na+ channels. Metabotropic—slow synaptic transmission. Quisqualate; Regulation of second messengers (cAMP and Inositol) ...
NMDA Blockers. NMDA. Stimulated by chemical called glutamate; Over stimulation causes decreased nerve cell function and eventually nerve cell death. Agents.