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Quoted phrase not found in phrase index: "prostaglandin-endoperoxide synthase"
Page 1
Non-steroidal anti-inflammatory drugs and the gastrointestinal tract.
Tai FWD, McAlindon ME. Tai FWD, et al. Clin Med (Lond). 2021 Mar;21(2):131-134. doi: 10.7861/clinmed.2021-0039. Clin Med (Lond). 2021. PMID: 33762373 Free PMC article.
Selective cyclo-oxygenase (COX)-2 inhibitors are as effective as adding PPIs in preventing upper and lower gastrointestinal complications. COX-2 inhibitors are suggested in those with high cardiovascular risk and the addition of PPI in those with high …
Selective cyclo-oxygenase (COX)-2 inhibitors are as effective as adding PPIs in preventing upper and lower gastrointestinal co …
COX Inhibitors.
Qureshi O, Dua A. Qureshi O, et al. 2023 Mar 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Mar 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31747202 Free Books & Documents.
COX inhibitors are medications used in the management and treatment of chronic pain syndromes. ...This activity reviews the indications, action, and contraindications for COX inhibitors as valuable agents in the management of a variety of different pai …
COX inhibitors are medications used in the management and treatment of chronic pain syndromes. ...This activity reviews the in …
Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond.
Rao P, Knaus EE. Rao P, et al. J Pharm Pharm Sci. 2008 Sep 20;11(2):81s-110s. doi: 10.18433/j3t886. J Pharm Pharm Sci. 2008. PMID: 19203472 Free article. Review.
RESULTS: A brief history of the development of NSAIDs and the market withdrawal of selective COX-2 inhibitors is explained, followed by the description of prostaglandin biosynthesis, COX isoforms, structure and function. ...This is followed by a section that …
RESULTS: A brief history of the development of NSAIDs and the market withdrawal of selective COX-2 inhibitors is explained, fo …
A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation.
Yang HH, Duan JX, Liu SK, Xiong JB, Guan XX, Zhong WJ, Sun CC, Zhang CY, Luo XQ, Zhang YF, Chen P, Hammock BD, Hwang SH, Jiang JX, Zhou Y, Guan CX. Yang HH, et al. Theranostics. 2020 Mar 26;10(11):4749-4761. doi: 10.7150/thno.43108. eCollection 2020. Theranostics. 2020. PMID: 32308747 Free PMC article.
Methods: The metabolism of CYPs/COX-2-derived ARA in the lungs of LPS-induced ALI was investigated in C57BL/6 mice. The COX-2/sEH dual inhibitor PTUPB was used to establish the function of CYPs/COX-2 dysregulation in ALI. ...
Methods: The metabolism of CYPs/COX-2-derived ARA in the lungs of LPS-induced ALI was investigated in C57BL/6 mice. The COX-2/ …
Colorectal Carcinoma, Cyclooxygenases, and COX Inhibitors.
Ganduri V, Rajasekaran K, Duraiyarasan S, Adefuye MA, Manjunatha N. Ganduri V, et al. Cureus. 2022 Aug 30;14(8):e28579. doi: 10.7759/cureus.28579. eCollection 2022 Aug. Cureus. 2022. PMID: 36185863 Free PMC article. Review.
Therefore, COX inhibition by non-steroidal anti-inflammatory drugs (NSAIDs) targeted against both the isoforms COX-1 and COX-2 have been studied for decades in anticipation of preventing the occurrence of colorectal carcinoma in high-risk populations. This ar …
Therefore, COX inhibition by non-steroidal anti-inflammatory drugs (NSAIDs) targeted against both the isoforms COX-1 and CO …
Thiazoles and Thiazolidinones as COX/LOX Inhibitors.
Liaras K, Fesatidou M, Geronikaki A. Liaras K, et al. Molecules. 2018 Mar 18;23(3):685. doi: 10.3390/molecules23030685. Molecules. 2018. PMID: 29562646 Free PMC article. Review.
Inflammation is a natural process that is connected to various conditions and disorders such as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase isoenzymes (COX-1, COX-2) are responsible for the production of prostaglandin …
Inflammation is a natural process that is connected to various conditions and disorders such as arthritis, psoriasis, cancer, infections, as …
Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective.
Chahal S, Rani P, Kiran, Sindhu J, Joshi G, Ganesan A, Kalyaanamoorthy S, Mayank, Kumar P, Singh R, Negi A. Chahal S, et al. ACS Omega. 2023 May 9;8(20):17446-17498. doi: 10.1021/acsomega.3c00692. eCollection 2023 May 23. ACS Omega. 2023. PMID: 37251190 Free PMC article. Review.
Nevertheless, there is mounting evidence of cardiovascular side effects from COX-II inhibitors that resulted in the withdrawal of market-approved anti-COX-II drugs. ...To address this gap, herein we present an overview of chemical structures and inhibitory ac …
Nevertheless, there is mounting evidence of cardiovascular side effects from COX-II inhibitors that resulted in the withdrawal …
COX-2 Inhibitors and Gastric Cancer.
Wang Z, Chen JQ, Liu JL. Wang Z, et al. Gastroenterol Res Pract. 2014;2014:132320. doi: 10.1155/2014/132320. Epub 2014 Oct 12. Gastroenterol Res Pract. 2014. PMID: 25371669 Free PMC article. Review.
Both COX-dependent and COX-independent pathways have a role in the anticancer efficiency of COX-2 inhibitors. However, enthusiasm is thwarted by the potential toxicity, that is, gastrointestinal toxicity of nonselective COX-2 inhibitors a …
Both COX-dependent and COX-independent pathways have a role in the anticancer efficiency of COX-2 inhibitors. Ho …
Selective cyclooxygenase-2 inhibitors.
Golden BD, Abramson SB. Golden BD, et al. Rheum Dis Clin North Am. 1999 May;25(2):359-78. doi: 10.1016/s0889-857x(05)70073-9. Rheum Dis Clin North Am. 1999. PMID: 10356423 Free article. Review.
The preliminary in vivo experience with COX-2-selective inhibitors has provided evidence for proof of concept for the COX-1 and COX-2 hypothesis, namely that the selective inhibition of COX-2-derived prostaglandins is sufficient to inhibit infla …
The preliminary in vivo experience with COX-2-selective inhibitors has provided evidence for proof of concept for the COX …
COX-2 inhibitors.
Becker RC. Becker RC. Tex Heart Inst J. 2005;32(3):380-3. Tex Heart Inst J. 2005. PMID: 16392224 Free PMC article. Review.
The totality of data--the vascular biology and dinical trial data available to date--support the following conclusions: if COX-2 inhibitors are to be used, they should be considered as 2nd- or 3rd-line agents. ...COX-2 inhibitors increase the risk for …
The totality of data--the vascular biology and dinical trial data available to date--support the following conclusions: if COX-2 i …
11,601 results
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