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MDD Antidepressants, molecular side of anti-depressants e.g. serotonin and norephrine re-uptake inhibitors (SNRIs), serotonin and norephrine re-uptake inhibitors (SNRIs) increase synaptic norepinephrine, MRI correlated with Behavioral improvement, BDNF expression may hypothetically contribute to neurogenesis (in adult mammals limited to hippocampus and olfactory bulb), hippocampus a CREB phosphorylation, PFC decreased activity MRI, SSRIs - Selective serotonin re-uptake inhibitors increase synaptic serotonin, molecular side of anti-depressants e.g. monoamine oxidase inhibitors, Deep brain stimulation by Helen Mayberg (Emory) neuron 2005 - 4 of 6 improvements, serotonin and norephrine re-uptake inhibitors (SNRIs) increase synaptic serotonin