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AZ genetics - JDN Rev, increased prevalence of a-beta 41 in chr 1, APP linked to early onset, early onset encourages genetic testing, Volga Germans have FOUNDER EFFECT, 3 dominant causal genes are in chr 1, Volga Germans see Tom Byrd, Genetics and AZ focused on 3 dominant causal genes, 3 dominant causal genes are in chr 21, also APO-e alters clearance of a-beta 41, PS 1 linked to early onset