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MDD FINAL reduced, Brainstem stimulate Paraventricular Nucleus (PVN), anxiety in adult mice, Water where excess of Phlegm, Neurochemistry is a malfunction of Chemistry - The chemical hypothesis, Antidepressants (1) produce speedy metabolism effects, subthalmic nuclei e.g. deep-brain stimulation, ENVIRONMENTAL interactions such as childhood trauma, Chemistry - The chemical hypothesis focuses on chemicals, Hippocampus inhibit Hypothalamic Pituitary Adrenal (HPA) axis, Uncertainty about sufficient number of depressed individuals! now Single most expensive disorder in Western societies!