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MDD FINAL, Brain includes Brainstem, Trytophan does not affect Mood, deep-brain stimulation has caused suicide, Modern (20-21 centuries) is a Biology based approach, Monoamine Neurotransmitters namely serotonin (5-hydroxytryptamine 5-HT), Treatment namely ECT, Early Postnatal Development leads to anxiety-type behavior, catabolism/ re-uptake inhibited by Monoamine Neurotransmitters, support systems can reverse hyperactivity in Hypothalamic Pituitary Adrenal (HPA) axis, ELS present show superior response to therapy