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ALZ reduced, synaptic loss leads to plaques, early onset encourages genetic testing, temporal lobe includes Hippocampus, Alzheimer's Disease (AD) affected by Environment, Alzheimer's Disease (AD) preceded by Mild cognitive impairment, APP gene linked to early onset, Apolipoprotein APO-e synthesized from APO-e gene, Pharmacological medication e.g. Memantine, Mild cognitive impairment associated with APO-e4 (below), Amyloid Precursor Protein (APP) synthesized from APP gene