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MDD Reduced JDN Rev, morphological alterations include Reductions, EARLY antidepressant Treatment (animals) can enhance sprouting, NO EFFECT in absence of BDNF signaling, ECT is VERY EFFECTIVE, Early Life Stress (ELS) Nemeroff 2004 covers ENVIRONMENTAL interactions, synaptic contacts of axons, ELS present only marginally better on combined, EARLY antidepressant Treatment (animals) increase expression & signaling of Brain-derived neurotrophic factor PROTEIN (BDNF), ELS present show superior response to therapy, morphological alterations are New neurons (neurogenesis)