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2 MDD FINAL -=JDN, neurofibrillary tangles focus of the tau hypothesis, diet in life course, amyloid protein synthesized from APP, brain cells in Alzheimer's undergo cell cleavage, cognitive symptoms of Alzheimer's are either early onset Alzheimer's, brain cells in Alzheimer's affected by biochemistry of Alzheimer's, Alzheimer's candidate genes in Alzheimer's candidate loci, Aricept taken with vitamin E, cognitive symptoms of Alzheimer's have treatment, 30s - 65 include Volga Germans