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Integument, Skin Consists of 4 types of cells, Hair follicle invagination of epidermis hair bulb at terminal dilation s.germ.-like cells hair hair core of hair - medullary cell cortical cells cuticle cells internal root sheath cells- keratinized outer sheath of hair external RS cells - continuous w/ epi. same layers as epi, stratum lucidum NOT mitotic thin, no nuclei, orgs translucent contain eleidin very acidophilic in thick skin stratum granulosum NOT mitotic basophilic granules - keratohyalin membrane-bound granules GAGs and phospholipids barrier to microorgs, water, etc., Skin consists of 2 types, 4 types of cells ???? Merkel Cells Mostly in thick skin Mechano-receptive Associated w/ nerve endings 80 nm neurosecretory granules, Appendages ???? Sweat Glands, Dermis 2 layers Outer: Papillary Layer makes dermal papillae loose CT fibroblasts mast cells leukocytes, Integument ???? Skin, 2 layers (+) inner inner Hypodermis deep to dermis not actually skin, Merkel Cells Mostly in thick skin Mechano-receptive Associated w/ nerve endings 80 nm neurosecretory granules Located in stratum basale Mitotic cuboidal/columnar hemidesmosomes to bsmt desmosomes to each other nucleus protected by melanin