Warning:
JavaScript is turned OFF. None of the links on this page will work until it is reactivated.
If you need help turning JavaScript On, click here.
The Concept Map you are trying to access has information related to:
Clinical, Clots, Fibrinogen (I)->Fibrin-aggregate (Ia) -fibrin less soluble than fibrinogen -finbrinogen- (-)charged center peptides -thrombin attacks gamma-chain S-S bond ->cleaves charged peptides ->soft clot XIIIa catalyst (transamidase) Cross-linked hard clot -covalent links, Fibrinogen (I)->Fibrin-aggregate (Ia) -fibrin less soluble than fibrinogen -finbrinogen- (-)charged center peptides -thrombin attacks gamma-chain S-S bond ->cleaves charged peptides ->soft clot Fibrin Structure 2 tripeptides bridged by disulfide bonds -A,B chains w/ N-terminal S-S bonds, Clinical Chemistry Isozymes Ex: lactate dehydrogenase (LDH1-5) HHHH, HHHM, HHMM, HMMM, MMMM tetrameric isozymes -increase in HHHH, HHHM fraction->MI usually more HHHM than HHHH LDH1,2-myocardium, RBCs LDH3-brain, kidney LDH5-liver, sk. mm., Clinical Chemistry Serum levels as indicators Problems-specificity, speed, no cause IDed, levels may drop if tissue dies or blood occluded, Clinical Chemistry Isozymes CPK Isozymes: MM,MB,BB for muscle, brain large increase in MB->MI ->also by sk. mm. damage -athletes have lots of MB, Clot formation Intrinsic Pathway Damaged tissue surface->platelet binds -via VWF on subendoth. collagen -uses XII, XI, IX, X (9-12), Ex: lactate dehydrogenase (LDH1-5) HHHH, HHHM, HHMM, HMMM, MMMM tetrameric isozymes -increase in HHHH, HHHM fraction->MI usually more HHHM than HHHH LDH1,2-myocardium, RBCs LDH3-brain, kidney LDH5-liver, sk. mm. Coupled to a stain NADH reduces PMH reduced PMH then oxidizes NBT ->blue formazan, Prothrombin (II)-Xa->thrombin (IIa) -serine protease -cleaves Arg-Gly bonds -requires Va, Xa, Ca, phospholipid -Va, Ca, phospholipid cofactors -prothrombin N-terminus -w/ gamma-carboxyglutamate -binds Ca Thrombin catalyst Anti-thrombin III -inhibits thrombin -prevents spurious clots -heparin increases ATIII binding to thrombin -inhibits IX,X,XI,II, Clinical Chemistry Serum levels as indicators Cardiac Troponins I, T -they are 'IT' to find MI -diff isozymes in sk. m./cardiac m. -monoclonal antibodies w/ specificity -nearly complete specificity for card. mm. dmg -use ELISA or radioimmunoassay (RIA) hand-held devices, Clot formation Extrinsic Pathway Trauma signal-> VII->VIIa, X