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This Concept Map, created with IHMC CmapTools, has information related to: MELAS.cmap, RFLP reveals a pathogenic point mutation, 17-year old white female presents with vomitting, genetic testing specifically PCR, 17-year old white female presents with headache for several days, mitochondria site of Tricarobxylic Acid Cycle, NADH/NAD+ ratio which inhibit enzymes of Tricarobxylic Acid Cycle, metabolic therapies such as CoQ10, Reactive Oxygen Sepcies cause damage to proteins, pathogenic point mutation in mtDNA, CoQ10 will stabilize Oxidative Phosphorylation, bilateral hearing loss suggestive of mitochondrial disorder, progressive muscle weakness symtoms can be reduced by metabolic therapies, PCR and RFLP, Oxidative Phosphorylation will not produce ATP, SKeletal Muscle Biopsy reveals ragged red fibers, Tricarobxylic Acid Cycle is blocked initiating anaerobic glycolysis, tRNA which will distrupt translation, pyruvate to lactic acid, mitochondrial disorder causing her to undergo further diagnostic testing SKeletal Muscle Biopsy, ATP will result in visual abnormalities