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This Concept Map, created with IHMC CmapTools, has information related to: Hormone Tx 1, Destruction of Adrenal Cortex Symptoms of progressive weakness, fatigue, poor appetite, and weight loss (among others)., Hypothalmic malfunction, ↓ TRH Hypothyroidism, 1° thyroid malfunction, lack of TH neg. feedback on pituitary TSH secretion, and TRH from hypothalmus. Hypothyroidism, Pituitary Malfunction lack of neg. feedback to hypothalmus release of TRH by TSH and thyroid TH Hypothyroidism, Symptoms of progressive weakness, fatigue, poor appetite, and weight loss (among others). positive "lab tests" Diagnosis of Adisson's Disease