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This Concept Map, created with IHMC CmapTools, has information related to: Methoxyflurane, Blood across the respiratory membrane Increases Gap junction channel closing times, Junctional conductance by decreasing gap junction channel opening times Alters Tissue excitability, Emergency analgesic (trauma) Route Inhalational (3ml) analgesia after 6-8 breaths, Liver (hepatotoxic) Excreted Lungs, Blood across the respiratory membrane Binds NADH dehydrogenase, Blood across the respiratory membrane Binds to GABA receptor, Tissue excitability Reduces Pain, Methoxyflurane (volatile anaesthetic) Indications Emergency analgesic (trauma), Tissue excitability Induces Muscle relaxation, Blood across the respiratory membrane Reduces Junctional conductance by decreasing gap junction channel opening times, Methoxyflurane (volatile anaesthetic) Indications Anaesthetic, Inhalational (3ml) analgesia after 6-8 breaths Absorbed by Blood across the respiratory membrane, Blood across the respiratory membrane Binds to Glycine receptor, Blood across the respiratory membrane Binds to Ca++ activated potassium channel, Blood across the respiratory membrane Activates Calcium dependent ATPase in sarcoplasmic reticulum, Liver (hepatotoxic) Excreted Kidneys, Blood across the respiratory membrane Binds to Glutamate receptor, Pain Metabolised Liver (hepatotoxic), Blood across the respiratory membrane Binds D subunit of ATP synthase, Calcium dependent ATPase in sarcoplasmic reticulum By increasing Fluidity of lipid membrane