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This Concept Map, created with IHMC CmapTools, has information related to: Bcell development, activated B cell markers CD20/ CD21, heavy chain rearrangement H-chain gene, Rearrangement of immunoglobulin genes then Delete self-reactive B cells, Germinal center formation ???? affinity maturation, isotype switching need CD40, cytokine signals types stem cell factor, activated B cell Tcell dependent IL-4 IL-6 IL-10 IFN gmma, Helper T cells and FDC into plasma cells, somatic hypermutation mutate genes V region, independent of antigen 1st phase Rearrangement of immunoglobulin genes, 2. Large polysaccharide cross-links BCR, pre B cell rearrangement Light chain (k & l), Foreign antigen activates mature B cells, T-independent antigens types 1. polyclonal activator (mitogen), H-chain gene rearrangement 1st chromosome, Periphery (blood) ???? activated B cell, CD40 costimulatory B cells express, activated B cell Tcell independent Plasma cells, T2 B cell differentiate into activated B cell, H-chain gene rearrangement DNA D-J segment of heavy chain