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This Concept Map, created with IHMC CmapTools, has information related to: Tcell development, medulla cells antigen- presenting dendritic cells, self-MHC molecules (not MHC) aka Self peptide, TCR gene loci types alpha beta, TCR gene loci types gamma delta, cytokines affect inflammation Pro-inflammatory cytokines, antibody mediated differentiate Th2 CD4, IFN-gamma activate macrophage, Co-stimulation example B7 (APC) with CD28 (T cell), MHC I establish CD8, cell mediated differentiate T CD8, MHC I supress CD4, antibody mediated differentiate IL-2/ IL-2R, medulla cells Macrophages, self-MHC molecules (not MHC) on medulary epithelium, T cell maturation Differentiation, CD3 complex tells when bound to specific antigen, perforin facilitates granzyme entry, cell activation types B and T cell, Th1 CD4 secrete IL2, MHC II establish CD4