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This Concept Map, created with IHMC CmapTools, has information related to: joint pathology, Gout monoarthritis start 1st metacarpal underexcretion of uric acid (90%) overproduction of uric acid (10%) crystals are needle shaped and negative birefringent, Osteoarthritis predisposing factors age, obesity trauma, joint deformity), Joint pathology monosodium urate cyrstals in joint Gout, underexcretion of uric acid (90%) overproduction of uric acid (10%) crystals are needle shaped and negative birefringent classic presentation asymetric joint distrib. joint swollen, red, and painful MTPjoint of big toe (podagra) Tophus formation, NSAIDs, glucocorticoids, colchicine preventive (chronic) xanthine oxidase inhibitors (allopurinol) (prevents over production of Uric acid), asymmetric pattern affected joint swollen, red, and painful Synotivits, Tenosynovitis, and Dermatitis treatment ????, Joint pathology Mechanical Osteoarthritis, S. aureus Streptococcus Neisseria Gonorrhoea classic presentation asymmetric pattern affected joint swollen, red, and painful Synotivits, Tenosynovitis, and Dermatitis, Rheumatoid arthritis predisposing factors females>males anti-IgG Ab (rheumatic factor) HLA-DR4, Xray (subchondral cyst, osteophytes eburnation, sclerotic bone asymmetrical joint narrowing) classic presentaiton pain in weight bearing improves with rest non-inflammatory, Rheumatoid arthritis inflammatory cytokine mediated and hypersensitivity (type III and IV) Pannus formation in joints (MCP, PIP) ulnar deviation of fingers baker cyst (no DIP involvement) inc. synovial fluid, asymetric joint distrib. joint swollen, red, and painful MTPjoint of big toe (podagra) Tophus formation treatment NSAIDs, glucocorticoids, colchicine, Gout predisposing factors >males after large protein meal or alcohol consumption (dec. uric acid excretion), Joint pathology Autoimmune Rheumatoid arthritis, Joint pathology bacteria septic arthritis (infectious), Pannus formation in joints (MCP, PIP) ulnar deviation of fingers baker cyst (no DIP involvement) inc. synovial fluid classic presentation morning stiffness > 30 min symmetric joint systemic symptoms (fever, fatigue, pleuritis, pericarditis), Osteoarthritis joint wear and tear Xray (subchondral cyst, osteophytes eburnation, sclerotic bone asymmetrical joint narrowing), septic arthritis (infectious) infection by S. aureus Streptococcus Neisseria Gonorrhoea, morning stiffness > 30 min symmetric joint systemic symptoms (fever, fatigue, pleuritis, pericarditis) treatment NSAIDs, glucocorticoids, disease modifying agents (TNF-alpha inhibitors, methotrexate, sulfasalazine), pain in weight bearing improves with rest non-inflammatory treatment NSAIDs, intra-articular glucocorticoids