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This Concept Map, created with IHMC CmapTools, has information related to: hypersensitivity rxn, Cytotoxic Ab against cell Ag complement IgG, IgM three mech Ab cellular dysfunc. or anti-recp. Ab, IV (cell mediator) mech T-lymphocyte- macrophage and cytotoxic rxn, I (anaphylactic) mediators primary, Delayed ex. IPPD TB sarcoid fungal infec. some parasites AIDS, primary ex. Histamine, III (Immune complex) mech -IgG, IgM, IgA against antigen -deposited in tissues -Complement, neutrophilic inflammatory rxn, IV (cell mediator) examples Granulomatous disease TB fungus sarcoid graft rejection viral diseases tumor surveillance, antibody dep. cell mediated cytoxicity ex. Hashimoto's thyroiditis autoimmune diseases, -IgG, IgM, IgA against antigen -deposited in tissues -Complement, neutrophilic inflammatory rxn causes lysis and/or opsonization or dysfunc., I (anaphylactic) mediators secondary, Cytotoxic Ab against cell Ag complement IgG, IgM three mech antibody dep. cell mediated cytoxicity, T-lymphocyte- macrophage and cytotoxic rxn types Delayed, in situ (antigen deposited) Ab binds to antigen, initiated by CD4 T cells phagocytized by macrophages, complement mediated ex. transfusion rxn erythroblastosis fetalis autoimmune hemolytic anemia goodpastures syndrome - (glomeruli - not immune complex) pemphigus vulgaris, Hypersensitivity Reactions types IV (cell mediator), T cell mediated ex. graft rejection viral infection (CMV,herpes) tumor cell surveillance, initiated by CD4 T cells by Antigen+Macrophage Macrophage reprocesses Ag reprocessed Ag on surf. macrophage CD4 T cell activation release cytokines actiate lymphocytes, fibroblast, histocytes epithelioid histiocytes aggregation of histiocytes (granuloma forms), II (cytotoxic) mech Cytotoxic Ab against cell Ag complement IgG, IgM, T-lymphocyte- macrophage and cytotoxic rxn types T cell mediated