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This Concept Map, created with IHMC CmapTools, has information related to: Autoimmune, Nucleolar Ab to nucleolar RNA, +ANA (not specific) help differentiate between other autoimmunities by patterns Speckled, autoimmune types Mixed CT disease, anti-dsDNA & anti-smith (specific) (low serum complement) smith is ribonucleo- proteins, SLE increased incidence females 1-30 y/o African-American, inflammatory myopathies affect skeletal muscles, SLE increased incidence drugs, Juvenile RA absent RF, type III free DNA binds to anti-DNA (immune complexes, limited lab test anticentromere Ab, inflammatory myopathies types inclusion body myositis, CREST syndrome stands for Calcinosis Raynaud's esophageal dysmotility sclerodactyly telangiectasia, SLE lab test false +, inflammatory myopathies types dermatomyositis, cutaneous features causes malignant hypertension (onion skinning), inflammatory myopathies may occur with systemic sclerosis, SLE mech hyperactive B cells (CD4 Tcells stim B cells), Rim/peripheral Ab to dsDNA, Sjogren's syndrome increased incidence middle aged - older females, cutaneous features causes small vessels disease