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This Concept Map, created with IHMC CmapTools, has information related to: GI Wk 1 Liver, Detoxification in the Liver alcohol, Phase 1 most commonly Oxidation by cytochrome P450, Xenobiotic metabolism of acetaminophen via cytochrome P450 produces Reactive intermediate, hepatic sinusoids lined with Kupffer cells (macrophages), portal triads drain to hepatic sinusoids, portal vein travel in portal triads, Detoxification in the Liver method Biotransoformation, liver lobules 3 types are liver acinus, Lysosomal Degradation Benefit Recycle functional groups, or they can be oxidized to generate ATP, Phase 2 process Addition of glutathione by glutathione-S-transferase, N-acetyl cysteine which improves Conjugation, Reactive intermediate that is sequestered by N-acetyl cysteine, Phase 2 process Sulfonation by sulfotransferase, liver lobules 3 types are portal lobule, Phase 1 then Phase 2, Detoxification in the Liver method Lysosomal Degradation, Conjugation leading to Excretion, Biotransoformation first Phase 1, Anatomy organized as liver lobules, Lysosomal Degradation Process Enzymes cleave sugar moieties, fatty acids, sulfates from large molecules