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This Concept Map, created with IHMC CmapTools, has information related to: Draft1 (main), <math xmlns="http://www.w3.org/1998/Math/MathML"> <mmultiscripts> <mtext> Ca </mtext> <none/> <mtext> 2+ </mtext> </mmultiscripts> <mtext> influx </mtext> </math> ???? <math xmlns="http://www.w3.org/1998/Math/MathML"> <mrow> <mtext> ↑ intracellular </mtext> <mmultiscripts> <mtext> Ca </mtext> <none/> <mtext> 2+ </mtext> </mmultiscripts> </mrow> </math>, accumulation of endosome ???? ↓ lysosomal-endosomal fusion, ↓ dense lysosomes ???? accumulation of endosome, ↓ lysosomal-endosomal fusion ???? ↓ degradation of waste products, inadequate autolysosomal reformation ???? ↓ mTor reactivation, replacement of dysfunctional mito'l network and short mito'l network ???? <math xmlns="http://www.w3.org/1998/Math/MathML"> <mrow> <mtext> loss of mito'l </mtext> <mmultiscripts> <mtext> Ca </mtext> <none/> <mtext> 2+ </mtext> </mmultiscripts> <mtext> buffering capacity </mtext> </mrow> </math>, cell shrinkage and membrane blebbing ???? APOPTOSIS, α-Galactosidase deficiency ↑ Gb3 subtrates, ↓ mTor reactivation ???? ↓ IP3, inhibition of catabolic enzymes and permeases ???? secondary substrate accumulation, <math xmlns="http://www.w3.org/1998/Math/MathML"> <mrow> <mtext> ↓ </mtext> <mmultiscripts> <mtext> o </mtext> <mtext> 2 </mtext> <none/> </mmultiscripts> </mrow> </math> ???? ↓ ATP prod'n by mitochondria, ↓ degradation of waste products ???? accumulation of waste products, ↓ autophagic flux ???? ↑ LC3 II, Caspase cascade 3,6,7 ???? Lamin A, Lamin A ???? cell shrinkage and membrane blebbing, defective mito'l membrane ???? leakage of cyt c, defective mito'l membrane ???? <math xmlns="http://www.w3.org/1998/Math/MathML"> <mrow> <mtext> leakage of </mtext> <mmultiscripts> <mtext> e </mtext> <none/> <mtext> - </mtext> </mmultiscripts> <mtext> along respiratory complex </mtext> </mrow> </math>, cell switch to anaerobic respiration ???? lactic acid production, <math xmlns="http://www.w3.org/1998/Math/MathML"> <mrow> <mtext> prod'n of </mtext> <mmultiscripts> <mtext> H </mtext> <mtext> 2 </mtext> <none/> </mmultiscripts> <mmultiscripts> <mtext> O </mtext> <mtext> 2 </mtext> <none/> </mmultiscripts> <mtext> (ROS) and </mtext> <mmultiscripts> <mtext> O </mtext> <mtext> 2 </mtext> <none/> </mmultiscripts> <mtext> in intermembrane space and matrix </mtext> </mrow> </math> ???? <math xmlns="http://www.w3.org/1998/Math/MathML"> <mrow> <mmultiscripts> <mtext> OH </mtext> <none/> <mtext> - </mtext> </mmultiscripts> <mtext> (ROS) </mtext> </mrow> </math>, caspase 9 ???? Caspase cascade 3,6,7