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This Concept Map, created with IHMC CmapTools, has information related to: Spirochetes, Treponema virulence factors Fibronectin coat, B. burgdorferi host deer, Hyaluronidase leads to minimal immune response, Syphilis diagnosis no culture available, Leptospira found in urine of mucuous membranes skin breaks, serologic tests non-specific non-treponemal tests, e.g. VDRL, stain poorly no stain available darkfield microscopy, serologic tests specific Treponemal, e.g. FTA-ABS, primary S. tissue damage releases cardiolipin antibodies, OSPs Bind Fibronectin Fibronectin coat, Spirochetes genus Leptospira, Fatigue, migratory pain; neurologic, cardiac disorders if untreated can lead to Migratory polyarthritis, tick infects human, secondary S. tissue damage releases cardiolipin antibodies, Treponemal, e.g. FTA-ABS based on treponemal antibodies, Syphilis diagnosis serologic tests, latent S. can lead to tertiary S., Treponemal, e.g. FTA-ABS detects primary S., Leptospira causes Leptospirosis, T. pallidum subpecies pallidum causes Syphilis