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This Concept Map, created with IHMC CmapTools, has information related to: Med Chem Functional Groups, are non-adjacent to aromatic or double bonds becoming ???? electron withdrawing groups (EWG), Resonance (mesomeric) occurs at adjacent double bonds or lone pairs, Organic Compounds are comprised of Hydrogen, electron donating groups (EDG ???? nucleophilic, electron withdrawing groups (EWG) groups w/ permanent positive charge is MOST EW > triflouro methyl > carbonyl > then halogens makes electrons less available for hydrogen bonding (protonation), increasing, Organic Compounds are comprised of Carbon, Functional groups which affects steric dimensions, makes electrons less available for hydrogen bonding (protonation), increasing ???? acidity of functional groups, electronics results in 2 types of effects Resonance (mesomeric), electronics results in 2 types of effects Intrinsic Induction, +/- charge to be equally shared (stabilization) can change level of acidity of functional groups, hydroxyl, thiol, or methoxy (ether) groups ???? are non-adjacent to aromatic or double bonds becoming, adjacent double bonds or lone pairs which allows +/- charge to be equally shared (stabilization), Intrinsic Induction negative induction caused by electron withdrawing groups (EWG), solubility based on polarity, Intrinsic Induction depends on atom/functional group's overall electronegativity, polarity two types non-polar, ???? acidity of functional groups, electron donating groups (EDG are adjacent to aromatic ring or double bonds groups w/ negative charges or lone pairs are MOST ED > hydroxyl > amine > thiol > methoxy (ether) > alkyl groups, atom/functional group's overall electronegativity Common atoms ranked on electro. value F > O > Cl > N > Br > I > S > C > H > P