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This Concept Map, created with IHMC CmapTools, has information related to: Untitled, In 80% of MG, pathology occurs by ACh-receptor antibodies destroying Nicotinic Receptors (ACh Substrate), Cholinergic Syndrome ???? CNS Effect Treatment, Female black widow spider Latrodectus mactrans bite cause ????, Neostigmine 0.1mg/kg Initial IV 5mg (10mL) of 5mg/10ml vial, Nicotinic Receptors (ACh Substrate) affects receptors of Skeletal Muscle (N1 or NM), Patient: 20 yo F Weight: 110lbs (50kg) Height: 5'6 Test dose Edrephonium, Female black widow spider Latrodectus mactrans bite cause chest pain, Pyridostigmine (Mestinon) Response occurs in 10-15 minutes, Cholinergic Syndrome experience the following symptoms lacrimate, Pyridostigmine (Mestinon) Pharmacological treatments Inhibition of ACh-esterase activity, increasing [ACh], Acetylcholine Disorders ???? Female black widow spider Latrodectus mactrans, block Acetylcholine formation and release may experience vomiting, Nerve (Sarin) Gas Strongly Inhibits ACh-esterase, Patient: 20 yo F Weight: 110lbs (50kg) Height: 5'6 symptoms Muscle weakness for 1 month, Arms and legs tire rapidly with exertion Correlates with Experiences severe muscle fatigue & weakness (Chronic), Skeletal Muscle (N1 or NM) Symptoms Experiences severe muscle fatigue & weakness (Chronic), Inhibition of ACh-esterase activity, increasing [ACh] Saturates leftover receptors with ACh Nicotinic Receptors (ACh Substrate), block Acetylcholine formation and release may experience dry mouth, Neostigmine (Prostigmin 15mg) 0.5mg/kg Oral 25mg (1 and 2/3 tablet) every 8 hours, Patient: 20 yo F Weight: 110lbs (50kg) Height: 5'6 symptoms Arms and legs tire rapidly with exertion