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This Concept Map, created with IHMC CmapTools, has information related to: Wk 11, Diagnostic Procedures Hand Shake Test, Inhibts Acetlycholinesterase Increases Concentration of Acetylcholine, Diagnostic Procedures Electromyography (Repetitive Nerve Stimulation), Neostigmine (Prostigmin) MOA Inhibts Acetlycholinesterase, 60-960 mg/d PO XR 30-60 min onset, 6-12 hour duration, Symptoms Facial paralysis, Pyridostigmine (Mestinon) Dosage (adults) 60-960 mg/d PO, Acetylcholine Receptors Antibodies binds here Blocks and reduces number of acetylcholine receptors at neuromuscular junction, Axon Terminal Releases Acetylcholine Binds to Acetylcholine Receptors, Myasthenia Gravis Patient Information 20 YOF 110lbs, Seronegative Myasthenia Gravis Test Patient do not have antibodies against acetylcholine receptors, immune MG is targetting other receptors ie. MuSK, Acetylcholinesterase inhibitor increases Concentration of Acetylcholine, Diagnostic Procedures Edrophonium Chloride Test, 5 mg IV 10 mg/ ml 0.5 ml IV, Patient Information 20 YOF 110lbs Case Symptoms Arms and legs easily tire, displaying signs of weakness, Patient Information 20 YOF 110lbs Case Symptoms Trouble swallowing food, Myasthenia Gravis Symptoms, Edrephonium (Tesilon) Diagnosis Dosage 0.1-0.5 mg/kg, Symptoms Breathing Difficulty, Myasthenia Gravis Treatment Options