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This Concept Map, created with IHMC CmapTools, has information related to: Week 12, Neuromuscular junction Acetylcholine released into space Acetylcholine binds to ion-channel receptors, Incremental IV 1.8-3 mg, Receptors Muscarinic M5, Blockade of ACh receptors at Neuromuscular junction, 1.8-3 mg Repeat Every 5 min doubling dose, Acetylcholine binds to ion-channel receptors Causes Ion channels to open, Acetylcholine in serum exerts direct effect on vascular tone Cells responde by Increasing production of nitric oxide, Receptors Muscarinic M3, Atropinization Followed by 10-20% of total dose every hour, M3 Effect Smooth Muscle, Continuous Binding Will Degrade Eventually, Works as Neuromodulator Arousal, M5 G-coupled Gq, Ligand-gated ion channels Permeable to Sodium, Potassium, Calcium, Works as Neuromodulator Plasticity, N2 Ligand-gated ion channels, Signs/Symptoms Skeletal Muscle Fasciculation, M3 G-coupled Gq, Signs/Symptoms CNS Effects Dizziness, M1 G-coupled Gq