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This Concept Map, created with IHMC CmapTools, has information related to: MG Bitches Edited by Kevin, Mechanisms for Altered ACH Action Neostigmine, Physostigmine, Disopropylflurophosphate, Pesticides Block ACH binding to Esterase reversibe, Centrally Active ???? Baclofen, Myasthenia Gravis Treatments Neostigmine 10 mL IV initial dose, Myasthenia Gravis (Autoimmune disease) Decreased Nicotine Receptor Availability Pathology Normal Pathology (non-Myasthenia Gravis), Non-Depolarizing/Competitive Blockers Pancuronium, Centrally Active ???? Tizanidine, Mestinon (pyridostigmine) Inexpensive, Difficulty chewing/swallowing Symptoms Weakness of eye muscles, Depolarizing Blockers ???? Succinyl-Choline, Myasthenia Gravis (Autoimmune disease) Decreased Nicotine Receptor Availability Symptoms Difficulty breathing, Lower signal transmission Therefore Reduced Muscle Contraction or Muscle Relaxation, Neostigmine (Acetylcholinesterase) Blocks Acetylcholinesterase Activity Increased Overall Acetylcholine, Mestinon (pyridostigmine) If it works Improves within hours, Mechanisms for Altered ACH Action Organophsophate Poisoning Irreversibly Bind to ACHesterase, Difficulty chewing/swallowing Symptoms Fatigue, 20 year old Female 110 lbs 5'6" Suspected Myasthenia Gravis Test/Diagnosis 0.5 mL IV push Edrephonium, Immune Problem (antibody problem) Prednisone, Centrally Active ???? Chlorzoxazone, Mestinon (pyridostigmine) Few serious side effects, Nicotinic Receptor (ligand gated ion channels) At the Neuromuscular junction (N1/Nm type receptor) Results in Channel Opening