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This Concept Map, created with IHMC CmapTools, has information related to: MG Bitches...Another One, Neostigmine Mechanism of Action Blocks Acetylcholine Esterase, Presynaptic release of ACh in the presence of receptor-blocking antibodies antibodies block ACh from binding to Nicotinic receptors (ligand gated ion channels), Nicotinic N1 receptors blocking Acetylcholine from binding Decreased ACh Binding, Mechanism of Action Blocks Muscarinic ACh receptors, Neostigmine 0.1 mg/kg IV initial dose, repeated after 5 min if required for the reversal of muscle relaxation, Succinylcholine Treatment Oximes, 0.5 mL IV push Edrephonium Immediate Improvement (Contraction) Myasthenia Gravis, Too much Acetylcholine in Synaptic Cleft Laryngeal Spasms, Allows Na+ and K+ to pass Resulting in Normal signal transmission, Mechanisms for Altered ACh Action Nicotinic Receptors, Succinylcholine Dosage for 150 lb 5.11 mL, Acetylcholine Binds to Acetylcholine Receptor, Given until signs of atropinization appear For serious cases like Organophosphate poisoning Continue treatment: Maintenance dose (30% of atropinization dose) for 1 - 2 weeks., Nicotinic Receptors Voltage Gated Ganglionic Nicotinic Receptors (Ng), N2, or Nn, Myasthenia Gravis Pathology Presynaptic release of ACh in the presence of receptor-blocking antibodies, Immune Problem (antibody problem) Others, Muscarinic Receptors G-Protein (Gq) Coupled M1, M4, M5, Myasthenia Gravis (Autoimmune disease) Treatment of Symptoms, Decreased Contractions Clinical symptoms Defecation, Urination, Miosis, Bronchospasm, Emesis, Sweating, Salivation, Lacrimation, Paralysis, Necrosis, Nicotinic receptors (ligand gated ion channels) At the Neuromuscular junction (N1/Nm type receptor) Results in lower channel opening