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This Concept Map, created with IHMC CmapTools, has information related to: Thrombosis, JE 54 YOM 250 lb 60 Pack year smoker Question Should he take fish oil?, Statins Lower LDL Cholesterol, Veneous Leads to Deep Vein Thrombosis, Hypercoagulability ???? Vascular Damage, (-) NO (+)Local Mediators (+) ACE-A III Resulting in Inflammation Vasoconstriction Thrombosis Plaque Rupture, Hypercoagulability ???? Circulatory Stasis, Arterial Leads to Peripheral Arterial Clot Heart Attack Stroke, Thrombosis Pharmacotherapy Warfarin, Vascular Damage ???? Circulatory Stasis, Capillary refill time Symptom of PAD ɮ seconds, Hypertension Diabetes High Cholesterol Risk factors for Endothelial Dysfunction, Omega-3 Fatty Acids Which causes (+)HDL Cholesterol (-) LDL Choesterol, COX 1 Promotes decreased platelet aggregation, Endothelial Dysfunction Which Causes (-) NO (+)Local Mediators (+) ACE-A III, COX 1 and COX 2 inhibits prostacyclin (PG12), JE 54 YOM 250 lb 60 Pack year smoker PMH Hypertension Diabetes High Cholesterol, prostacyclin (PG12) inhibits platelet aggregation, Pulmonary Embolism S/sx Cough SOB Bloody Sputum, JE 54 YOM 250 lb 60 Pack year smoker PMH Blood Clot entered lungs; 6 mo ago, Cox Inhibitors (Aspirin) Two Types of Doses High dose 325mg