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This Concept Map, created with IHMC CmapTools, has information related to: Coagulation Cascade, Recruits platelets through complex signaling pathway thrombin acts on factor 8 on platelet Factor 8a, exposed Tissue Factor (TF) TF directly affects factor 7 Factor 7 converted to factor 7a by TF, Factor 10a Factor 10a joins factor 5a 10a+ 5a forms Prothrombinase, Factor 8a Factor 9a binds with Factor 8a to make Tenase Tenase acts on factor 10, Thrombin also activates amplification cascade (intrinsic factor) Thrombin acts on factor 11 on platelet Factor 11a, factor 5a Factor 10a joins factor 5a 10a+ 5a forms Prothrombinase, Recruits platelets through complex signaling pathway Thrombin acts on factor 11 on platelet Factor 11a, Fibrin forms Clot, Traps thrombin, plasminogen, tissue activator(tPA) Plamoginogen with tPA Converted to Plasmin, Thrombin also activates amplification cascade (intrinsic factor) thrombin acts on factor 8 on platelet Factor 8a, Thrombin activates factor 13 to 13a Helps stabilzes Fibrin with cross-links Fibrin binds together Fibrin forms Clot, Traps thrombin, plasminogen, tissue activator(tPA), Thrombin also activates amplification cascade (intrinsic factor) Thrombin acts on factor 5 on platelet factor 5a, Converted to Plasmin Plasmin and Fibrin Fibrin degradation product Breakdown of clot, Cut damaged endothelium exposed Tissue Factor (TF), Cut damaged endothelium Recruits platelets through complex signaling pathway, Tenase acts on factor 10 Factor 10 converted Factor 10a, Factor 9a Factor 9a binds with Factor 8a to make Tenase Tenase acts on factor 10, Factor 11a Factor 9 activated by 11a Factor 9a, 10a+ 5a forms Prothrombinase Pro-thrombinase activates factor 2 factor 2(pro-thrombin) converted to factor 2a (thrombin), factor 2(pro-thrombin) converted to factor 2a (thrombin) Factor 2a (thrombin) activates factor 1 (THROMBIN) Thrombin also activates amplification cascade (intrinsic factor), Recruits platelets through complex signaling pathway Thrombin acts on factor 5 on platelet factor 5a