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This Concept Map, created with IHMC CmapTools, has information related to: Drug Metabolism cMAP, Methadone Mortality causes Accumulated toxicity, constipation non-Rx diet modifications, Verapamil ER tab 240 mg hs ~1 wk sho complaint(s) Depression, Methadone 100 mg/day for 2 years contraindications Grapefruit Juice, Verapamil ER tab 240 mg hs ~1 wk sho Contraindication Both can lower BP (but seems to tolerate it), diet modifications increase Liquid intake, Depression wants St. John's Wort, Verapamil Moderate Reduced bioavailability of Verapamil, Miralax DDI digoxin, 45 y.o. male med history HT, 3 options 2 replace verapamil with propranolol, St John's Wort Moderate Reduced bioavailability of Verapamil, Methadone 100 mg/day for 2 years Contraindication Both can lower BP (but seems to tolerate it), laxative options Miralax, 3 options 1 replace verapamil with furosemide, depression non-Rx -exercise -vacation -puppy -sunlight, DDI ???? Verapamil, Verapamil DDI increase potency w/ SSRIs, laxative options Senna: effective for opioid induced constipation, replace verapamil with furosemide cautions Monitor BP