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This Concept Map, created with IHMC CmapTools, has information related to: Cancer lecture 3, ???? Look for 2 aromatic rings with 2 molecules b/w (2 molecule chain,3 lines), Anti-metabolites Interupt S-phase Purine Antagonists, Allopurinol (Xanthine oxidase inhibitor) ????, Coenzyme Leucovorin, Decarbazine MOA block Inosine, Pyrimidine Antagonists MOA block thymidylate synthase, Misc. Antineoplastic Agents Hormone therapy Corticosteroids, Purine Antagonists drug 6-MP & 6-TG (6-mercaptopurine), inhibit DNA polymerase and/or DNA chain elongation drug Cladribine Clofarabine Fludarabine Gemcitabine, DNA polymerase inhibitors MOA inhibit DNA polymerase and/or DNA chain elongation, Misc. Antineoplastic Agents stop transcription Hydroxyurea (Droxia), Misc. Antineoplastic Agents Enzyme therapy Aspariginase, Anti-metabolites Interupt S-phase DNA polymerase inhibitors, Methotrexate (Trexall) ????, Cytarabine (ARA-C) want P3, Antifolates folic acid analogs Pemetrexed (Alimta) Pralatrexate (Folotyn), 5-FU (uracil analog) ????, inhibits DHFR (Dihydrofolate Reductase) ???? Stops conversion of DHF to THF, Antifolates folic acid analogs Methotrexate (Trexall), Hydroxyurea (Droxia) ????