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This Concept Map, created with IHMC CmapTools, has information related to: hypersensitivity, SCr = 2.3 mg/dL (admission value = 1.1 mg/dL) ???? Temperature = 99.5 ° F (low grade fever), First-Line Therapy ???? Clindamycin 600 mg every 8 h IV or 300–450 mg qid po, Case 6: Acute Interstitial Nephritis (AIN) & MRSA ???? MRSA, Case 6: Acute Interstitial Nephritis (AIN) & MRSA ???? Medication Management, First-Line Therapy ???? Doxycycline, minocycline 100 mg bid po, Case 6: Acute Interstitial Nephritis (AIN) & MRSA ???? Lab Values, Lovenox Prophylaxis ???? Enoxaparin 30 mg SQ once daily, Monitoring ???? Electroytes, AIN Characterized by: Immune-related kidney injury caused by infections, medications, etc, AIN ???? Reaction Type, Reaction Type ???? Non-dose dependent, AIN ???? Treatment, MRSA Characterized by: Gram-positive bacteria resistant to Methicillin, a more virulent strain of staphylococcus, DDI's ???? Moderate interaction with Lovenox and Vancomycin (increased risk of bleeding), Non-dose dependent ???? Illness presentation 10-14 days after exposure, Non-dose dependent ???? Improves upon cessation, First-Line Therapy ???? Ceftaroline 600 mg bid IV, Non-dose dependent ???? Rapidly recur with re-exposure, First-Line Therapy ???? Vancomycin 30 mg/kg/day in 2 divided doses IV, SCr ???? 0.6-1.2 mg/dL