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This Concept Map, created with IHMC CmapTools, has information related to: Lupus, Case 2 Diagnosis Symptoms, Symptoms ???? Persistent joint pain, Butterfly rash Positive Antihistone Antibody test Drug-induced Lupus, Pharmacological ???? Topical hydrocortisone cream as need for joint stiffness, Pharmacological ???? Indomethacin to reduce swelling, stiffness, and pain, Petechial rash Positive Antihistone Antibody test Drug-induced Lupus, Non-Pharmacological ???? Avoid sun exposure or wear sunscreens that block UVA/B, Case 2 Diagnosis PPD Test, Case 2 Current Medications INH + Rifampin, Case 2 Diagnosis Drug-Induced Lupus, Has completed 4 months of treatment Causes Lupus, INH + Rifampin 26 week course for TB Has completed 4 months of treatment, Cotrimoxazole (SMX/TMP) for 10 days 10 day course for staph infection 10 day course for staph infection, Symptoms ???? Mild fever, PPD Test Positive Presence of Induration, PPD Test ???? Type IV hypersensitivity (T-cell mediated): determine if pt has developed and immune response to M. tuberculosis, Case 2 Recommendations Non-Pharmacological, Drug-Induced Lupus ???? Type III hypersensitivity (Immune-complex mediated), Presence of Induration ???? TB Confirmed, Pharmacological ???? Should be reversed once the INH are stopped