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This Concept Map, created with IHMC CmapTools, has information related to: Viral pathogenesis part 2, immunopathology B cells enhancement of viral infeciton, Viral Pathogenesis (Part II) Mechanisms of cell injury transformation of normal cells, Viral Pathogenesis (Part II) Mechanisms of cell injury immunopathology, Viral Pathogenesis (Part II) Mechanisms of cell injury inhibition of host protein & RNA synthesis, Viral Pathogenesis (Part II) shedding release of virions from an infected individual, Viral Pathogenesis (Part II) Mechanisms of cell injury viroporins, stimulate body cells to release inflammatory vasoactive peptides, bradykinins, histamines, etc. results in vasodilation & increased mucous secretion, inhibition of host protein & RNA synthesis leads to - loss of membrane integrity - leakage of enzymes from lysosomes - cytoplasmic degradation, Syncytium formation by enveloped viruses results in lysis of syncytias, cytolytic viruses induce necrosis, apoptosis, or pyroptosis, viroporins results in modification of cellular membranes, Viral Pathogenesis (Part II) virulence capacity of infection to cause disease, Viral Pathogenesis (Part II) Mechanisms of cell injury Syncytium formation by enveloped viruses, Viral Pathogenesis (Part II) virulence genetic determinants, immunopathology innate cytokine storm, Viral Pathogenesis (Part II) patterns of infection sporadic endemic pandemic epidemic, immunopathology CD8+ T cells apoptosis of infected cells, immunopathology B cells virus-antibody complexes lead to vasculitis, glomerulonephritis, & mental confusion, capacity of infection to cause disease degree virulent avirulent attenuated, Viral Pathogenesis (Part II) determinants of susceptibility host genes, age, gender, pregnancy, nutrition, smoking, air pollution, stress