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This Concept Map, created with IHMC CmapTools, has information related to: 3A Apoptose, Bid valt uiteen tBid, Apaf-1 ????, FAS ligand of TNFR-1 bindt aan Death receptor, caspase 3 Activeert caspase 6, Death receptor DISC complex (FADD of TRADD/pro-caspase 8 en of 10), ATM/ATR kinase fosforyleert actief p53, caspase 3 activeert caspase 6 en 7, caspase 8 en caspase 10 activeert caspase 3, Cytochrome c Migratie naar cytoplasma Apoptosoom (cytochroom C/Apaf-1/pro-caspase 9-complex), Chk 1 en Chk 2 Fosforyleert actief p53, intrinsieke pathway verloopt via mitochondrien, caspase 8 en caspase 10 activeren Bid, actief p53 activeert Bcl 2, caspase 7 activeren APOPTOSE, caspase 6 activeren APOPTOSE, Bcl 2, Apoptosoom (cytochroom C/Apaf-1/pro-caspase 9-complex) caspase 9, actief p53 activeert PUMA, caspase 3 Activeert caspase 7, DISC complex (FADD of TRADD/pro-caspase 8 en of 10) activatie caspase 8 en caspase 10