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This Concept Map, created with IHMC CmapTools, has information related to: Cymbalta, 30 milligram (blue and white capsule, printed "Lilly 3240 30 mg") Contains: 33.7mg duloxetine hydrochloride Inactive ingredients: FD&C Blue No. 2, gelatin, hypromellose, hydroxypropyl methylcellulose acetate succinate, sodium laurel sulfate, sucrose, sugar spheres, talc, titanium dioxide, triethyl citrate, 60 milligram (blue and green capsule) Available formulations Printed "Lilly 3237 60mg", Cymbalta (duloxetine hydrochloride) Clinical Pharmacology Mechanism of Action Unknown precise mechanism regarding central pain inhibition and anxiolytic actions; believed to be related to potentiation of serotonergic and nonadrenergic activity in CNS, Cymbalta (duloxetine hydrochloride) Clinical Pharmacology Pharmacokinetics, Cymbalta (duloxetine hydrochloride) Chemistry Empirical Formula C18H19NOS•HCl Molecular Weight 333.88 Structural Formula White to slightly brownish white solid, slightly water soluble, Cymbalta (duloxetine hydrochloride) Dosage Forms (delayed-release capsules) 20 milligram (green capsule, printed "Lilly 3235 20mg"), Cymbalta (duloxetine hydrochloride) Chemistry Chemical Structure, Cymbalta (duloxetine hydrochloride) Dosage Forms (delayed-release capsules) 30 milligram (blue and white capsule, printed "Lilly 3240 30 mg"), Printed "Lilly 3270 60mg" Contains: 67.3mg duloxetine hydrochloride, iron oxide yellow Printed "Lilly 3237 60mg", 60 milligram (blue and green capsule) Available formulations Printed "Lilly 3270 60mg", Cymbalta (duloxetine hydrochloride) Clinical Pharmacology Pharmacodynamics - Potent inhibitor of neuronal serotonin and norepinephrine reuptake - Less Potent inhibitor of dopamine reuptake - No significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, GABA receptors, Inactive ingredients: FD&C Blue No. 2, gelatin, hypromellose, hydroxypropyl methylcellulose acetate succinate, sodium laurel sulfate, sucrose, sugar spheres, talc, titanium dioxide, triethyl citrate Contains: 22.4mg duloxetine hydrochloride, iron oxide yellow 20 milligram (green capsule, printed "Lilly 3235 20mg"), Pharmacokinetics Distribution ????, Pharmacokinetics Excretion Elimination half life: 12 hours (range: 8-27 hours), Cymbalta (duloxetine hydrochloride) Clinical Pharmacology Indications and Usage, Cymbalta (duloxetine hydrochloride) Clinical Pharmacology Warnings, Printed "Lilly 3270 60mg" Contains: 67.3mg duloxetine hydrochloride, iron oxide yellow Inactive ingredients: FD&C Blue No. 2, gelatin, hypromellose, hydroxypropyl methylcellulose acetate succinate, sodium laurel sulfate, sucrose, sugar spheres, talc, titanium dioxide, triethyl citrate, Cymbalta (duloxetine hydrochloride) Drug Class Selective serotonin and norepineprhine reuptake inhibitor (SNRI), Pharmacokinetics Absorption ????, Cymbalta (duloxetine hydrochloride) Dosage Forms (delayed-release capsules) 60 milligram (blue and green capsule)