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Centrosomes, Normal Centrosomes are composed of Centrioles, p21 inhibits Cdk2/CyclinE, p53 transactivates p21, Equal segregation of chromosomes occurs during Mitosis, Cdk2/CyclinE initiates Centrosome Amplification, Centrosome Amplification results in Multiple Centrosomes, Centrosome Amplification occurs during S phase, Multipolar Spindle can result in Unequal segregation of chromosomes, p53 transactivates MDM2, Centrosome duplication results in two Normal Centrosomes